Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-

Name	LJI308
Synonyms	LJI308 CS-2181 LJI 308 LJI-308 2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-
CAS	1627709-94-7
EINECS	604-604-1

Molecular Formula	C21H18F2N2O2
Molar Mass	368.38
Solubility	DMSO: ≥ 32 mg/mL
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
In vitro study	LJI308 inhibits S6K1 with an IC 50 of 0.8 μM. LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells. LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%. Cell Viability Assay Cell Line: HTRY-LT cell lines Concentration: 1-10 μM Incubation Time: 96 hours Result: Decreased cell viability by up to 90%.

Last Update：2024-01-02 23:10:35

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Product Name: LJI308 Visit Supplier Webpage Request for quotation
CAS: 1627709-94-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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